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Charles Sagerström, Ph.D.
PROFESSOR,
DEPARTMENT OF PEDIATRICS


B.A., Biology
 Macalester College 
1987

Ph.D., Immunology
 Stanford University
1993

Postdoctoral Fellow
Whitehead Institute/MIT
1993-1997

​My research career started in college with an interest in Immunology that I pursued through graduate school.  I was particularly interested in cell fate decisions among immune cells and this led me to carry out postdoctoral research studying embryonic development.  I started my own research group at the University of Massachusetts Medical School in 1997, and in 2019 I relocated to the University of Colorado Medical School.  My group has a long-standing interest in understanding how embryonic development is programmed at the level of gene expression.  We primarily use zebrafish as a model organism and we apply genome-wide approaches to study transcriptional regulation in early embryogenesis.

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Current Lab Members 

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​Yong-ll Kim,
​Ph.D.​
post doctoral fellow
B.S., Biology
Chungnam National University
2009


M.S., Biology 
Chungnam National University
2011


Ph.D., Microbiology
​
Wonkwang University School of Medicine
​2017 



​When I was an undergraduate student, I worked with a master’s degree student who was trying to generate a mutant line of zebrafish using insertional mutagenesis.
After joining my master’s degree program, I worked on a project to characterize cells that form bone. I generated a bone-specific col10a1
:GFP transgenic zebrafish.
​

I joined my Ph.D. program and started working on my project that focused on the role of peroxisome-related genes during zebrafish development. During this time, I generated several alleles of zebrafish mutants and transgenic zebrafish related to peroxisome biology.
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​Currently I work in the Sagerström lab as a postdoctoral research fellow. Here, my research focuses on investigating the role of hindbrain-related genes during zebrafish development.
EMAIL YONG-IL
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Ethan Wright, M.Sc.
Sr. PROFESSIONAL RESEARCH ASSISTANT 
B.S., Genetics
University of Georgia
2016 

M.Sc., Molecular Biology University of Colorado
​2019
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​My research interest is in transcriptional regulation during early neurogenesis. 

While at The University of Georgia, I performed my undergraduate research in Jonathan Eggenschwiler's lab. My project focused on Sonic Hedgehog signaling in mouse neural tube closure.

​My graduate research was performed in Eugenia Killian's lab. My work focused on the alternative splicing factor, Caper, and its role in Drosophila neuron development. 

I joined the Sagerström lab in the summer of 2019. My current project focuses on  the early transcription factors Meis and Prep. The primary focus of the project is to understand the role of these factors in hindbrain development; especially  during the transition from maternal to zygotic stages. These factors are uniquely  interesting as they are critical in the hindbrain during early development but then also play a key role in cancer during adulthood.
 
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Sylvia Nunez 
Ph.D. CANDIDATE
B.S., Integrative Biology University of Illinois at Urbana-Champaign
​2016

​
​During my undergraduate career at the University of Illinois at Urbana-Champaign, I had the opportunity to work in Dr. Felipe Soto-Adames's lab studying the molecular evolution of paralogous genes involved in muscle contractions in insects and decapods.

​I joined the Sagerström lab as a PhD student in Cell Biology, Stem Cells, and Development researching cell fate decisions at the midbrain-hindbrain boundary in zebrafish. 
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​Heather Reichenbach
Professional Research Assistant
B.A., Molecular, Cellular, & Developmental Biology
University of Colorado, Boulder
2021


​During my undergraduate studies I conducted research with Drs. Nolan Kane and Daniela Vergara, which 
consisted of assembling and annotating the Linum decumbens plastome, in addition to leading an evolutionary genetics analysis of a published,
non-domesticated Cannabis sativa genome assembly.

I joined the Sagerström Lab in Autumn 2021 and currently assist with genotyping and the established TALE transcription factor research involving Meis and Prep.
Email Heather
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Cameron Bennett
graduate student
B.S., Genomics and Molecular Genetics
Michigan State University
​2021


​While an undergraduate at Michigan State University, I had the opportunity to work in Dr. Ingo Braasch's lab.  My research focused on the functional analysis of the endothelin gene Edn4 in neural crest cells and their derivatives.

I joined the Sagerström lab as a Ph.D. student in the Molecular Biology program in 2022.
EMAIL CAMERON

Lab Alumni

Jelena Kresoja-Rakic, Ph.D. (2023) - Scientist
    ArtisanBio
​
Jessica Warns, Ph.D. (2022) - Adjunct Professor
    Northern State University, Aberdeen, SD
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