Principal Investigator
Charles Sagerström, PhD
Professor, Department of Pediatrics. B.A., Biology Macalester College 1987 PhD Immunology Stanford University 1993 Postdoctoral Fellow Whitehead Institute/MIT 1993-1997 My research career started in college with an interest in Immunology that I pursued through graduate school. I was particularly interested in cell fate decisions among immune cells and this led me to carry out postdoctoral research studying embryonic development. I started my own research group at the University of Massachusetts Medical School in 1997 and in 2019 I relocated to the University of Colorado Medical School. My group has a long-standing interest in understanding how embryonic development is programmed at the level of gene expression. We primarily use zebrafish as a model organism and we apply genome-wide approaches to study transcriptional regulation in early embryogenesis. |
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We are always interested in having qualified individuals join our lab!
Currently, we have postdoctoral openings available through the Section of Developmental Biology Postdoctoral Training Program. Click here for additional details. |
Current Lab Members
Jessica Warns, PhD post doctoral fellow B.S. Molecular Biology Muskingum University 2013 PhD Biochemistry and Molecular Biology University of North Dakota 2018 During my undergraduate studies, I had the opportunity to perform research on optimizing the detection of a transcript involved in Chronic Myeloid Leukemia known as BCL-ABL. During this time, I fell in love with research and decided to attend the University of North Dakota for graduate school. While I had several different projects, my thesis work involved investigating the role of a cholesterol metabolite in colon cancer, specifically 27-hydroxycholesterol on colon cancer cell proliferation and AKT signaling under my advisor Dr. Othman Ghribi. After I graduated with my PhD in 2018, I took a position at Fort Lewis College in Durango, CO as a visiting instructor of Biochemistry. After completing teaching, I began to work in the Charles Sagerstrӧm Lab as a postdoctoral fellow in 2019. My project involves studying the role of a transcription factor NF-Y in regulation of cilia genes and ciliogenesis. |
Yong-ll Kim, PhD POst doctoral Fellow B.S., Biology Chungnam National University 2009 M.S., Biology Chungnam National University 2011 PhD., Microbiology Wonkwang University School of Medicine 2017 When I undergraduate student, I was working with a master’s degree student who was trying to generate a mutant line of zebrafish using insertional mutagenesis. After joining the Master’s degree program, I worked on a project to characterize cells that form bone. I generated a bone-specific col10a1:GFP transgenic zebrafish. I joined Ph.D. program and started working on my project that focused on the role of peroxisome-related genes during zebrafish development. During this time, I generated several alleles of zebrafish mutants and transgenic zebrafish related to peroxisome biology. Now, I'm working in the Sagerstrom lab as a postdoctoral research fellow. Here, my research focuses on investiging the role of hindbrain related genes during zebrafish development. |
Ethan Wright, MSc PROFESSIONAL RESEARCH ASSISTANT B.S. Genetics University of Georgia 2016 MSc. Molecular Biology University of Colorado 2019 My research interest is in transcriptional regulation during early neurogenesis. While at The University of Georgia, I performed my undergraduate research in Jonathan Eggenschwiler's lab. My project focused on Sonic Hedgehog signaling in mouse neural tube closure. My graduate research was performed in Eugenia Killian's lab. My work focused on the alternative splicing factor, Caper, and its role in Drosophila neuron development. I joined the Sagerström lab in the summer of 2019. My current project focuses on the early transcription factors Meis and Prep. The primary focus of the project is to understand the role of these factors in hindbrain development; especially during the transition from maternal to zygotic stages. These factors are uniquely interesting as they are critical in the hindbrain during early development but then also play a key role in cancer during adulthood. |
